How Does CKD Stage 4 Lead to Joint Pain?

Some chronic disease patients may complain that they often suffer from joint pain. In serious case, extreme joint pain even can affect their life quality and interfere with their normal life. So how does CKD stage 4 lead to joint pain?

CKD stage 4 is an advanced stage. Kidney is an important organ for our body. In our daily life, the metabolic system continues to circulate. Meanwhile the wastes and toxins produce consistently. Under normal circumstances, those wastes and toxins will be eliminated out of the body in the form of urine. As kidney is damaged day by day, kidney needs to keep working for our body therefore GFR keeps losing and GFR 28 occur. When those wastes deposit in our body, it may destroys any systems in our body.

The prime culprit of joint pain in CKD is high levels of uric acid. Uric acid is the byproduct of purine and it is normally filtered out of body by kidneys. In right condition, the levels of uric acid keep at a constant level in body.

However, when kidneys fail to work properly, uric acid will not be removed by kidneys adequately, thus resulting in high levels of uric acid in body. Over time, the uric acid will form crystals. If the crystal deposits in joints, it can cause inflammation in the affected part, thus resulting in arthritis.


In addition, joint pain may be one sign of bone disease in CKD. Bone disease is a common complication of CKD. As the kidneys are impaired, they will to remove phosphorus from body. If the level of phosphorus in blood is too high, it will pull calcium out of bone to balance the levels of calcium and phosphorus in body.

As a result, bone disease will occur. Joint pain can become present among patients with bone disease.