The Cause Of Renal Failure

Renal failure has become a more common kidney disease and its etiopathogenesis are many, and even other kidney diseases development to the last also can lead to kidney failure, introduce some possible cause of renal failure

1.Hypovolemia: All kinds of reasons cause bleeding ,kidney and the liquid of gastrointestinal tract lost ,skin liquid lost(such as burn,excessive sweat)cause blood volume insufficiency .Hypovolemia make renal blood perfusion reduce ,GFR decline ,at the same time the sympathetic nerve excitation and vasopressin rise cause the renal blood shrink ,thus making the GFR decline more and causing renal failure .

2.Circulatory insufficiency:All kinds of reasons cause shock ,heart function and others circulatory insufficiency ,thus causing hypoperfusion ,GFR decline .Excessive use hypotensive drugs is also a inducing factors .

3.Serious infection and blood poisoning: All kinds of serious infection ,especially patients with blood poisoning can through renal ischemia and nephrotoxicity mechanism cause renal failure .

4.Serious trauma:Such as burn ,crush injury,serious fracture ,due to shock ,infection and injury make the organization release myohemoglobin ,easily occur renal failure .Serious burn will make a large number of liquid lost and intravascular hemolysis also prone to kidney failure.


5.Liver cirrhosis and ascites: At this time ,plasma renin-angiotensin-aldosterone system has already been activated ,vasopressin secretion increase cause water and sodium retention .Abnormal liver function make the drug detoxification ability decline .At this time if put ascites too fast it is easy to cause kidney failure ,this kind of patients with renal toxicity drugs are also prone to kidney failure .