The cause of the elevated creatinine

High creatinine is that due to the various causes of kidney in violation, the phenotypic changes of the damaged renal intrinsic cells, formation of pathological changes, stimulate renal fibroblasts into muscle in fibroblasts.

Said the next mechanism, into the muscle of fibroblasts and at the same time the infringement and inspired the inherent normal kidney tissues, happen the same pathological changes, thus formed the kidney, from part to whole, enlarge the spread process of JiFaShi, thus entered the organ damage period (i.e., kidney damage), at this time due to kidney damage, the discharge of waste function decreases, creates a condensation of creatinine and other toxins in the body, resulting in blood creatinine and urea nitrogen increased, urine creatinine decreased, double kidney filtration rate drop, etc.At the same time, patients will have high blood pressure, body height edema, etc.In addition, higher creatinine is how to return a responsibility also implicated the kidney damage of four periods:

1. The renal failure stage compensatory glomerular filtration rate (GFR) of 50 ml to 80 ml/min at this time also refers to the endogenous creatinine eradication rate (Ccr) decreased, but in more than 50 ml/min, serum creatinine under 178 mu moL/L, blood urea nitrogen under the tendency of 9 L, generally no clinical symptoms, storage is also called the kidney function decline period.

2. Renal failure decompensation period Ccr per minute, 25 to 50 ml, serum creatinine increased up to 178 mu moL/L (more than 2 mg/dL). The blood urea nitrogen up to 9 tendency/L (25 mg/dL) above, in addition to mild anemia, gastrointestinal symptoms, nocturia increased outside has no obvious discomfort, but in the tired, infection, blood pressure fluctuations or clinical symptom aggravating when eating too much protein, also known as nitrogen qualitative hematic disease stage.

3. Renal failure stage of Ccr 10 to 25 ml per minute, serum creatinine is 221-442 mu moL/L, 17.9 21.4 tendency for blood urea nitrogen/L, most have more apparent than the elimination of symptoms and symptoms of anemia, had mild metabolic acidosis abnormal metabolism of calcium and phosphorus, but no significant water and salt metabolism disorder, the renal function and role, said early uremia.


4. Uremic serum creatinine 442 mu moL/L blood urea nitrogen tendency for 21.4 L.Often appear all sorts of uremia symptoms such as anemia and severe nausea, vomiting, and a variety of neurological complications, and even coma, clear water and salt metabolism and acid-base balance disorder oliguria or anuria.When Ccr10m1, serum creatinine, 707 mu per minute moL/L called end-stage, also known as the late uremia.