Chronic Renal Insufficiency In The Pathogenesis

Chronic renal insufficiency is a complex disease, caused by chronic renal insufficiency due to the reason there are many, many of its symptoms are, so if chronic renal failure patients with chronic renal insufficiency not enough understanding, then perhaps adversely affected by illness , and then to bring his body very much harm. So what has chronic renal insufficiency in the pathogenesis? Here we explain in detail for.

1, various pathogenesis of impaired (including primary and secondary nephrotic kidney disease) resulting in damage to the kidneys local microcirculation, renal ischemia and hypoxia, renal vascular endothelial cell damage, thus attracting circulating inflammatory cell infiltration, the release of inflammatory mediators, inflammatory response, renal fibrosis initially started, this time showing partial kidney inflammation, glomerular basement membrane permeability changes, macromolecular albumin, blood cells leak, the clinical manifestations of protein PRO and occult blood in urine, along with the progression of renal fibrosis will be a little bit of development, hardening, but also a little bit of scope to expand.

2, impaired kidney cells will continue to release a series of toxicity caused by cytokines, growth factors, to promote healthy kidney function cell (mesangial cells, epithelial cells, fibroblasts) phenotypic transformation, continue to release material induced renal injury, increased kidney damage.

3, the transformed cell phenotype, in particular renal interstitial fibroblasts continue to secrete the conversion, a series of synthetic fibers can not easily be degraded collagen protein (extracellular matrix), the synthesis and degradation of extracellular matrix homeostasis Insuffcient , a large sedimentary accumulation in the kidney cells, replacing healthy kidney function units, resulting in glomerulosclerosis, tubular - interstitial fibrosis, renal vascular fibrosis.

4, along with the expansion of the area of ​​renal fibrosis progress, functional kidney tissue gradually becomes less persistent loss of kidney function, and ultimately the entire kidney scarring, the development of end-stage renal recession - uremia high creatinine.


The above is relevant to explain the pathogenesis of chronic renal insufficiency, and for chronic renal failure patients, seize the time to go to a regular hospital treatment is very necessary.