Why is Hepatitis B Can Lead to Glomerulonephritis

Kidney disease, experts say, if the patient is suffering from hepatitis B, we should note, this time from the need to prevent kidney disease also followed after. Hepatitis B could even lead to glomerulonephritis?

After suffering from hepatitis B, along with other diseases spate came after hepatitis B virus infection in human glomerular injury in the formation of immune complexes by the immune response or hepatitis B virus directly attacks the kidney tissue caused by glomerulonephritis, this type of nephritis is called hepatitis B associated glomerulonephritis.

hepatitis B associated glomerulonephritis clinically, mainly for patients with symptoms of proteinuria, hematuria, or nephrotic syndrome. One of the most typical pathological changes are membranous nephropathy. Glomerulonephritis associated with hepatitis B virus infection incidence rate of about 6.8% to 20.0%, more common in children.

Pathogenesis of this disease has not been elucidated, but a lot of research data indicate hepatitis B associated glomerulonephritis pathogenic mainly through the following ways:

First, hepatitis B virus antigen - antibody immune complex deposition caused by damage to the glomeruli, in this way can be pathogenic in two forms:

1, circulating immune complexes: the main body hepatitis B virus infection, and their serum antibody to form immune complexes in the blood circulation, deposition in the glomerular capillary loops, resulting in activation of the complement immune injury and disease.

2, in situ immune complex: mainly low molecular weight pass through the group hepatitis B virus e antigen on the glomerular membrane and implanted subcutaneously to hepatitis B virus e antibody immune complex is formed in situ, is deposited on the glomerular subcutaneous and disease.

Second, the virus directly infected kidney cells:

The researchers found a HBVDNA hepatitis B virus associated glomerulonephritis in patients with renal tissue, demonstrating hepatitis B virus may directly infect the kidneys.

Third, the hepatitis B virus infection and cellular immune autoantibodies cause damage:

Autoimmune damage and defects in immune function have a great relationship, after infection hepatitis B virus can stimulate the body to produce a variety of autoantibodies, such as: Can DNA antibodies, anti-cytoskeletal components antibodies; hepatitis B virus can cause infection of target cells damage to the target cells by cytotoxic T cell immunity, causing the body's own immune response.


By study found that hepatitis B virus antigen produced by the kidneys have injury, so patients with hepatitis B is also a large group of kidney disease.