What Causes Diabetic Nephropathy

1. Genetic Factors

The proportion of men who have diabetic nephropathy than women; research from the United States found in the same environment, African and Mexican-prone diabetic nephropathy compared with whites; the same race, some families prone to diabetic nephropathy, all these are It suggests genetic factors. Type 1 diabetes occurs 40% to 50% of microalbuminuria in type 2 diabetes during the observation period are only 20% to 30% of diabetic nephropathy, are indications that genetic factors may play an important role.

2. renal hemodynamic abnormalities

After early diabetic nephropathy can be observed in renal hemodynamic abnormalities, it showed high perfusion and glomerular filtration, renal blood flow and glomerular filtration rate (GFR) increases, and increase protein intake increased The more significant degree.

3. metabolic disorders caused by high blood sugar

High blood sugar, mainly through the kidney hemodynamics and kidney damage caused by metabolic abnormalities, including metabolic abnormalities lead to kidney damage mechanisms include: ① local glucose metabolism in renal tissue can form advanced glycation end by non-enzymatic glycosylation metabolite (AGES); ② polyol pathway activation; ③ diacylglycerol - activated protein kinase c pathway; ④ has glucosamine metabolism pathway. In addition to the above metabolic abnormalities involved in the early high filtration, more importantly, to promote the glomerular basement membrane (GBM) thickening and accumulation of extracellular matrix; increased glomerular hair.

How Serious Is Creatinine 1.8 for Diabetic Nephropathy Patients

Creatinine 3.2, BUN 66, Diabetic Nephropathy: How Serious is It

40% Kidney Function, Diabetic Nephropathy: What Are the Dangers and Precautions for This

Is Creatinine 3 a Severe Kidney Problem or the Starting Stage in Diabetic Nehropathy

What Kind of Disease is Proteinuria

4. Hypertension

Almost any diabetic nephropathy are associated with hypertension, hypertensive nephropathy in type 1 diabetes and microalbuminuria occur in parallel, and in the type 2 diabetic nephropathy often appear before. Blood pressure control is closely related to the development of diabetic nephropathy.

5. metabolism of vasoactive substances

The development and progression of diabetic nephropathy can have the metabolism of vasoactive substances exception. Including RAS, endothelin, prostaglandins family and growth factors and other metabolic abnormalities.

If you have any questions you want advice, you can contact us by email: chinakidneyhospital@gmail.com or Tel: +8613633219293.