What is the harm had nephritis patients after? Symptoms include abdominal pain of nephritis. Common symptoms. Part of nephritis patients gastrointestinal tract most commonly occurs with abdominal pain. Abdominal pain is given priority to with periumbilical and lower abdomen for paroxysmal colic, abdominal pain can be accompanied by nausea and vomiting and bloody urine, occasional vomiting blood, stool. So, got nephritis patients after have what harm, let's take a look at the expert's detail.
1, proteinuria can lead to kidney failure, mainly due to its non adaptive response of the change of the tubular cell biology. According to the current data show that the protein can directly regulate tubular function, change its growth characteristics and its cytokines and matrix proteins phenotypic expression, also can make the tubular basement side release PDGF, FN and MCP - 1, induce fibrosis process.
What is the harm had nephritis patients after
The mesangial toxicity of 2, proteinuria, there will be a serum protein in glomerular mesangial unceasing accumulation, lead to hyperplasia of mesangial cell damage, each department membrane matrix synthesis increases, resulting in glomerular sclerosis. And glomerular apolipoprotein B and apolipoprotein B deposition will eventually cause glomerular sclerosis.
3, the toxic effects of proteinuria may affect the proximal convoluted tubules, increased the amount of protein into the renal tubular epithelial cells, thereby increasing the activity of the lysosome, which means that the proteins made lysosome overflow into the tubular cell plasma, after due to cell damage, stimulates the production of lead to inflammation and scar. And may cause the deterioration of the tubular interstitial oxygen, cause lack of oxygen of tubular cells, make its damage.
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