About what factors related with lupus nephritis?Experts point out that specific as follows:
The psychological factors
Some studies reveal psychological stress can not only promote with lupus nephritis disease activity, and also may be the cause that causes with lupus nephritis.However, the intensity of stress response to the individual by individual quality, personality characteristics and the strength of the stressful life events, the influence of the duration and frequencyEnvironmental factors
(1) virus infectionMany scholars believe that the disease is associated with slow virus (C type of RNA viruses).In New Zealand with lupus nephritis patients detected with hybrid NZB mice/NAWF1 tissue C RNA virus, even though the patient groups have yet to prove exist this kind of virus, but can be detected in serum RNA - DNA antibodies.
(2) the sunlight or ultraviolet light
Under ultraviolet light skin horn cells secrete interleukin 1 stimulate B cells, and induce T cells to produce interleukin 2, and stimulate the immune system make the condition worse.
(3) The genetic factors in recent years, studies have shown that genetic factors in the pathogenesis of with lupus nephritis.Patients with lupus nephritis can have a family history, relative higher prevalence.
(4) The sex hormones
In view of the disease more women than men are also significant, and in the growth period, so that estrogen is associated with the disease occurred.Pregnancy can worsen half of the patients.Experimental animals to make the illness is aggravating, estrogen with lupus nephritis as an androgen can reduce the disease.Patients with this disease have been found for both men and women, the estrone hydroxylation products are increased, while testosterone is reduced.
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