Drug how to damage our kidneys

1. The renal vasoconstriction and renal blood flow reduced:

Non-steroidal anti-inflammatory drugs inhibiting prostaglandin synthesis, thus kidney vasodilation function abate, decreased renal blood flow and glomerular filtration rate.In mild kidney function damage, dehydration, other cases in the liver, prone to acute renal insufficiency, but more commonly is reversible.Captopril and converting enzyme inhibitors on the ball has strong expansion effect, small arteries can be decreased glomerular filtration rate.When bilateral renal artery stenosis, the higher the angiotensin Ⅱ ball small artery contraction of the enhancement is one of the important conditions to maintain glomerular filtration rate, and the lifting angiotensin converting enzyme inhibitors Ⅱ on the ball and the constriction of arterioles, reason can cause glomerular filtration rate fell sharply, through this mechanism can cause acute renal failure.

2. The renal tubular epithelial damage directly:

(1), epithelial cells of renal tubule phospholipase suppressed, cause lysosomal medullary change, cell damage and necrosis (amino glucoside can cause).
(2) the epithelial cells of renal tubule lysosomal enzyme and enzyme in vivo release of drug classification, and other organelles damaged cell necrosis;
(3) mitochondrial function by inhibiting renal tubular epithelial cell, cell respiratory distress and damage (some) can be caused by cephalosporin;
(4) renal tubular epithelial cell calcium accumulation (e.g., amino sugar glycosides);
(5) caused by free radicals damage;
6 Na +, K + atpase.

3. The activation of the immune mechanism:

Drug molecules cause Ⅳ type of allergy, or immunoglobulin mediated allergy, can cause acute interstitial nephritis.Type Ⅱ allergy caused by drug molecules can cause immune complex glomerulonephritis.Immune complex lesions, also can cause chronic interstitial nephritis.

4. Metabolic disorders or toxic metabolites cause kidney damage:

Some of the associated with the onset of chronic interstitial nephritis.

5. Drug deposition caused by renal tubular obstruction:

Acute renal failure caused by such as sp.
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